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THE ACE STUDY

 

The ACE study's enrollment period has just begun! We plan to enroll 100 individuals-  25 African American men, 25 African American women, 25 white men, and 25 white women.  We are working hard to fill these recruitment requirements, so click below to learn more!

A MESSAGE OF APPRECIATION

We are tremendously grateful to our research participants and our community volunteers for making our research a possibility!

RESOURCES OF INTEREST

  • Click here to visit Dr. William Hu's lab page - a neurologist at Rutgers University that we collaborate with for some of our projects

  • Click here to read some Frequently Asked Questions about lumbar punctures

  • Check out some brain-related health stories on "Your Fantastic Mind", a television series created through a partnership between Emory University and Georgia Public Broadcasting.

  • If you are in need of Alzheimer's or dementia related support please take a look at the Alzheimer's Association's Help and Support page

OUR MISSION

The Wharton laboratory is focused on Alzheimer’s prevention and investigates the influence of midlife vascular risk factors on Alzheimer's disease (AD) in mostly cognitively normal populations. We develop observational & clinical trials in hopes of reducing Alzheimer's disease in people most at risk, including individuals with a parental history of AD, African Americans, family caregivers, women and the LGBTQ community.

 

Areas of investigation include:

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  • Understanding the contribution of midlife vascular risk factors in AD and developing interventions to target the most relevant AD biomarkers including AD-related brain changes, inflammation, sleep, and heart health, in individuals at high risk for AD.

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  • Testing whether certain blood pressure medications penetrate the brain and act on Alzheimer's disease biomarkers, thereby potentially reducing AD risk.

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  • Testing potential racial differences in the way that blood pressure medications penetrate the brain and potentially influence AD risk, while at the same time investigating both physiological and sociological factors that may lead to these differences.

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  • Understanding how sex hormones in the body and in the brain influence an individual’s risk for AD.

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  • Adapting existing AD caregiver interventions to make the information more applicable to African Americans and the LGBTQ community.

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