Wharton lab
Our Research
Areas of Investigation:
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Understanding the contribution of midlife vascular risk factors in AD and developing interventions to target the most relevant AD biomarkers including AD-related brain changes, inflammation, sleep, and heart health, in individuals at high risk for AD.​
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Testing whether certain blood pressure medications penetrate the brain and act on Alzheimer's disease biomarkers, thereby potentially reducing AD risk.​
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Testing potential racial differences in the way that blood pressure medications penetrate the brain and potentially influence AD risk, while at the same time investigating both physiological and sociological factors that may lead to these differences.​
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Understanding how sex hormones in the body and in the brain influence an individual’s risk for AD.​ Adapting existing AD caregiver interventions to make the information more applicable to African Americans and the LGBTQ community.​
E2: Sex Hormones and Alzheimer's Disease Prevention Study
Enrolling new participants and participants who participated in previous studies (HEART, ASCEND, ACT) for a two year observational study looking at the relationship between blood and brain sex hormones and Alzheimer's Disease risk factors during middle age. If you are interested, click here to learn more!
HEART: Health Evaluation in African Americans Using RAS Therapy
An Alzheimer’s prevention-based research clinical trial to see if an FDA-approved blood pressure medication has beneficial effects in African-Americans by affecting the blood flow and the amount of plaque in the brain. Enrollment for this trial has concluded.
RISE
RISE is a research study conducted by Emory University, the University of Nevada, Las Vegas, and the University of Tennessee, Knoxville. RISE stands for Research Inclusion Supports Equity.
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The RISE study included a research registry created to help ensure the LGBTQIA+ community is represented in Alzheimer’s research.
